High mpv12/9/2023 ![]() ![]() The present study aimed to investigate these markers in the relapse and remission phases of JIA relative to healthy control subjects. No previous study has examined MPV and NLR in relation to disease status in patients with JIA. Elevated MPV and increased neutrophil/lymphocyte ratio (NLR) are associated with inflammation these parameters decreased during disease remission. MPV is easily determined at low cost using complete blood count devices. There are several important disadvantages to the use of CRP and ESR as a marker of JIA, including changes in serum concentrations associated with age and gender and the existence of co-morbid infection. Among JIA patients, high erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels are used as criteria for determining clinical disease activity. The primary goal of treatment is to prevent attacks that cause permanent articular damage, foster normal growth, and provide comfort for the patient. Repeated attacks may cause severe morbidity. JIA is a group of diseases that can induce severe articular damage occurring in the form of attacks. The annual incidence and the prevalence of JIA among individuals less than 16 years of age are 3.2/100000 and 19.8/100000, respectively. The etiology of JIA is unclear, however both genetic and autoimmune factors contribute to disease pathogenesis. A number of other diseases must be excluded in the diagnosis of JIA. Juvenile idiopathic arthritis (JIA) is a chronic inflammatory autoimmune rheumatic disease that occurs in children and adolescents. However, NLR was not a predictive marker of disease activity in patients with JIA. Regular treatment may decrease platelet activation in JIA patients. Our results suggest that MPV may be a useful marker of disease activity in patients with JIA. Mean PDW was significantly higher in patients with active disease (17.84 ± 1.06) compared with the control group (17.19 ± 0.93) (P=0.01). ![]() NLR was significantly higher in patients with active (2.11 ± 1.19) and inactive (2.03 ± 1.51) disease relative to the control subjects (1.33 ± 0.66) (P<0.001, P=0.017, respectively). Active disease was associated with significantly increased MPV (8.23 ± 1.16 fl) compared with inactive disease (7.00 ± 1. Routine laboratory methods were used to measure white blood cell count (WBC), platelet count (PLT), neutrophil count, lymphocyte count, hemoglobin (Hb), MPV, PDW, NLR, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) in all subjects of both the patient and control groups. The study included 115 patients with JIA (64 with active disease and 51 with inactive disease) and 64 age-gender matched healthy control subjects. In the present study, we aimed to determine the association between mean platelet volume (MPV), neutrophil/lymphocyte ratio (NLR), platelet distribution width (PDW) and clinical measures of diseases activity in children with JIA. ![]() Mean platelet volume (MPV) is an indicator of systemic inflammation. Juvenile idiopathic arthritis (JIA) is a chronic inflammatory arthritis characterized by periods of remission and relapse. ![]()
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